Phototherapy (Total 4855 Papers Found)

Genetic association studies have linked a number of single nucleotide polymorphisms (SNPs) with unconjugated hyperbilirubinemia. The present study was undertaken to validate the association of SNPs with development of hyperbilirubinemia in Indian neonates. Genotyping of five SNPs in two candidate genes was performed in 126 infants with hyperbilirubinemia and 181 controls by PCR-RFLP, Gene Scan analysis and direct DNA sequencing. Genetic polymorphisms of the UGT1A1 promoter, specifically the -327 ...
Agitation and sleep disturbance are problematic for people with dementia and their carers, and have been linked to disrupted circadian rhythms caused by a lack of exposure to light. Bright light therapy (BLT) offers a powerful and cost-effective alternative to pharmacological options, and can be easily incorporated into care routines. This article describes practical issues faced when implementing light therapy in a nursing home setting, and attempts to address existing perceptions about its eff ...
Introduction: Vitiligo is a chronic acquired disorder presenting with depigmented macules and patches. The response to treatment is variable as no single therapy produces predictably good results. Needling with topical 5% 5 fluorouracil in vitiligo has been found to be promising, effective and safe modality of treatment. Materials and methods: Three patients with stable vitiligo were on medical treatment and phototherapy for two to three years. All the patients were not satisfied in terms of rep ...
OBJECTIVE To compare the guidelines of the 10 Dutch neonatal intensive care units (NICUs) for the treatment of preterm infants with hyperbilirubinemia, in order to develop uniform threshold levels for the total serum concentration of bilirubin (TSB) above which treatment with phototherapy or exchange transfusion is indicated. DESIGN Survey. METHODS Guidelines for hyperbilirubinemia in preterm infants (gestational age < 32 weeks) from all 10 Dutch NICUs were obtained and compared with each ...
BACKGROUND Abnormal wound-healing after thyroidectomy with a resulting scar is a common dermatologic consultation. Despite many medical and surgical approaches, prevention of postoperative scars is challenging. OBJECTIVE This study validated the efficacy and safety of low-level light therapy (LLLT) using an 830/590 nm light-emitting diode (LED)-based device for prevention of thyroidectomy scars. METHODS AND MATERIALS Thirty-five patients with linear surgical suture lines after thyroidectomy ...
We have developed an indocyanine green-loaded perfluorocarbon (ICG/PFCE) nanoemulsion as a multifunctional theranostic nanomedicine which enables not only (19)F magnetic resonance (MR)/near-infrared fluorescence (NIRF) bimodal imaging but also subsequent photodynamic/photothermal dual therapy of cancer. The hydrodynamic size of ICG/PFCE nanoemulsions was 164.2 nm. The stability of indocyanine green (ICG) in aqueous solution was significantly improved when loaded on perfluorocarbon nanoemulsions. ...
Clofibrate is a glucuronosyl transferase inducer that has been proposed to increase the elimination of bilirubin in neonates with hyperbilirubinemia. This study was conducted to determine the therapeutic effect of clofibrate in term neonates with non-hemolytic jaundice. This study was conducted on 52 newborns with pathologic unconjugated jaundice in Qazvin children hospital. Newborns divided randomly in two groups. Case group treated with clofibrate and intensive phototherapy, while control grou ...
Vitiligo often induces severe cosmetic disfigurement in patients. Both nonsurgical (medical) and surgical approaches for repigmenting vitiliginous macules are described (Table 1). Currently PUVA therapy appears to be the best method in providing reasonable hope for achieving repigmentation. Guidelines for both topical and systemic PUVA are available. Furthermore, surgical graft of autologous epidermal sheet or cultured melanocytes (often combined with keratinocyte co-culture) can be introduced t ...
BACKGROUND Phototherapy is an effective and generally safe method of treating neonatal hyperbilirubinemia. However, there is some concern that it may affect cerebral blood flow velocity (CBFV) in newborns with fragile cerebral vasculature. OBJECTIVES To measure and compare the effects of two different phototherapy units, delivering similar irradiance, on CBFVs. METHODS Doppler flow velocities were measured in term infants under fluorescent overhead and fluorescent BiliBed phototherapy units, ...
Bright light therapy and the broader realm of chronotherapy remain underappreciated and underutilized, despite their empirical support. Efficacy extends beyond seasonal affective disorder and includes nonseasonal depression and sleep disorders, with emerging evidence for a role in treating attention-deficit/hyperactivity disorder, delirium, and dementia. A practical overview is offered, including key aspects of underlying biology, indications for treatment, parameters of treatment, adverse effec ...
We review recently patented methods and devices that allow for more effectively targeted phototherapy with fewer side effects. Among the new devices and methods reviewed here are narrow-band UVB (311- 313 nm) with a flat-type light source and the new xenon chloride excimer light (308 nm), both of which allow for targeted spot irradiation, limiting the unnecessary exposure of healthy skin to UV light. Some new devices are designed to selectively irradiate targeted nasal and oral mucosal tissue an ...
Several clinical guidelines for the management of infants with severe neonatal hyperbilirubinemia recommend immediate exchange transfusion (ET) when the risk or presence of acute bilirubin encephalopathy is established in order to prevent chronic bilirubin encephalopathy or kernicterus. However, the literature is sparse concerning the interval between the time the decision for ET is made and the actual initiation of ET, especially in low- and middle-income countries (LMICs) with significant reso ...
OBJECTIVE The present trial evaluated incorporation of bright light therapy in the treatment of chronic nonspecific back pain (CNBP). DESIGN A prospective, randomized, controlled, multicenter, open design with three parallel trial arms was used. SETTING Subjects received a novel therapeutic, an expected therapeutic ineffective low dose, or no light exposure at three different medical centers. PATIENTS A total of 125 CNBP patients reporting pain intensity of ≥3 points on item 5 of the Bri ...
The treatment of night eating syndrome, a disorder characterized by evening hyperphagia, morning anorexia, and insomnia, continues to gain attention with its inclusion in the DSM-V. Known treatments for NES include pharmacological, phototherapy, weight loss and dietary, and psychological interventions, which, together with the syndrome's clinical characteristics, support a treatment guiding biobehavioral model. The biobehavioral model proposes that a genetic predisposition, coupled with stress, ...
We report a case of a 48-year-old woman who presented with chronic essential pruritus and was successfully treated with the transdermal estradiol system because of menopausal discomfort. Suberythemogenic UVB phototherapy was proposed to the patient in order to control her pruritus. She developed hyperpigmentation at the application site of estradiol. To the best of our knowledge, this is the first report suggesting a direct relationship between estrogen and melanin synthesis in humans. ...
INTRODUCTION Neonatal jaundice is treated with phototherapy and requires continuous cardiorespiratory monitoring, which can induce parental anxiety. Within a very short time, parents receive the announcement of the diagnosis and of the need for a treatment in another unit with a new team of caregivers. OBJECTIVE To evaluate parents' anxiety and their feelings concerning the location of treatment concerning cardiorespiratory monitoring equipment (wired vs Wi-Fi wireless monitoring equipment) an ...
BACKGROUND The costs of psoriasis to a tertiary-level clinic vary considerably depending on the country of study and methods used. Hospitalisation and phototherapy have been significant cost components. This study was performed to estimate the distribution and relative magnitude of the costs of psoriasis to a tertiary-level clinic. METHODS Based on 233 patients, outpatient and phototherapy visits and the days hospitalised were collected from the treatment provider's records. The visit costs re ...
1 Effect of oral eicosapentaenoic acid on epidermal Langerhans cell numbers and PGD2 1 production in UVR-exposed human skin: a randomised controlled study 2 3 Suzanne M Pilkington, Neil K Gibbs, Patrick Costello, Susan P Bennett, Karen A 4 Massey, Peter S Friedmann, Anna Nicolaou, Lesley E Rhodes 5 Centre for Dermatology, Institute of Inflammation and Repair and School of Pharmacy, 6 Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK; 7 Centre for Dermatology, Salfor ...
bilirubinometer is somewhat more effective than clinical screening. If both transcutaneous index and clinical acumen were used simultaneously there would be considerably fewer false-positive screens. Discussion Previous studies evaluating the transcutaneous bilirubinometer have been carried out in Japan by Yamanouchi et al.,2 and in the USA by Hegyi et al.3 Hegyi et al.3 obtained a correlation coefficient of 0.77 in forehead measurements on 43 white term infants on no treatment compared with our ...
Erythema was not always a good parameter for acute solar damage and is much more difficult to use in darker skin types. While in the past photodermatology was mainly focused on Caucasian skin, the future, therefore, could be completely different. In addition, skin colour has not only a protective importance but also a social importance. This is another factor that should be taken into account. Photodermatology and the classification of photodermatoses will also become more globalised in the futu ...
In this study we have evaluated the use of blue light (peak at 415 nm) and a mixed blue and red light (peaks at 415 and 660 nm) in the treatment of acne vulgaris. One hundred and seven patients with mild to moderate acne vulgaris were randomized into four treatment groups: blue light, mixed blue and red light, cool white light and 5% benzoyl peroxide cream. Subjects in the phototherapy groups used portable light sources and irradiation was carried out daily for 15 min. Comparative assessment bet ...
BACKGROUND Various repigmentation patterns such as perifollicular, marginal, diffuse, and mixed configuration can occur in vitiligo. The aim of this study was to clinically assess the types of repigmentation patterns obtained with narrow-band ultraviolet B (NBUVB) phototherapy or targeted phototherapy using a 308 nm excimer laser and to reveal whether the repigmentation patterns have any relationship to the location of lesions, patient's age, duration of lesions, or speed of improvement. METHO ...
BACKGROUND Although hypotheses about the therapeutic mechanism of action of light therapy have focused on serotonergic mechanisms, the potential role, if any, of catecholaminergic pathways has not been fully explored. METHODS Sixteen patients with seasonal affective disorder who had responded to a standard regimen of daily 10000-lux light therapy were enrolled in a double-blind, placebo-controlled, randomized crossover study. We compared the effects of tryptophan depletion with catecholamine d ...
OBJECTIVE In this study, we investigated prospectively the incidence of significant hyperbilirubinemia and demographic and laboratory characteristics and pattern of serum bilirubin levels of near-term newborns (35-37 weeks' [245-265 days'] gestation) by comparing them with those of term newborns (38-42 weeks' [266-294 days'] gestation) longitudinally in the first 7 days of life; we also aimed to determine the value of an early (6th-hour) serum bilirubin measurement in predicting the development ...
Whole-body ultraviolet (UV)A1 (340-400 nm) phototherapy was first introduced 30 years ago, but is currently available in the UK in only three dermatology departments. A workshop to discuss UVA1 was held by the British Photodermatology Group in May 2009, the aim of which was to provide an overview of UVA1 phototherapy and its role in practice, and to identify areas in which further studies are required. The conclusions were that UVA1 phototherapy is an effective treatment in several inflammatory ...
The 430 pigment isolated from bilirubin-albumin solutions illuminated in vitro, decreased the bilirubin binding affinity of serum. This effect was demonstrated for both tightly and loosely bound bilirubin in serum, but in albumin solutions pretreated with charcoal only the binding of loosely bound bilirubin was decreased. This finding is of importance because a similar pigment has been isolated from the body fluids of an infant with Crigler-Najjar syndrome. The production and accumulation of 430 ...
Herein, a donor-acceptor-donor (D-A-D) structured small molecule (DPP-TPA) is designed and synthesized for photoacoustic imaging (PAI) guided photodynamic/photothermal synergistic therapy. In the diketopyrrolopyrrole (DPP) molecule, a thiophene group is contained to increase the intersystem crossing (ISC) ability through the heavy atom effect. Simultaneously, triphenylamine (TPA) is introduced for bathochromic shift absorption as well as charge transport capacity enhancement. After formation of ...
Although allergic rhinitis is not life threatening, it significantly influences the quality of a patient's life. This study is intended to evaluate the safety and efficacy of phototherapy with low-level energy of a 650 nm laser irradiation system in perennial allergic rhinitis patients. This clinical trial was an open-label, single-center study with 42 perennial allergic rhinitis subjects. Following laser irradiation in the nasal cavity with a laser irradiation system, the efficacy at weeks 1 th ...
A 54-year-old Caucasian male suffering from psoriasis had been treated in 1978 and 1980 with PUVA (cumulative UVA dose 492.5 J/cm2) and from 1980 to 1989 with UVB (cumulative UVB dose 264.5 J/cm2). Other occasional treatment had comprised the topical administration of glucocorticosteroids, dithranol or tar. In 1989, on the upper part of the patient's back a newly developed pigmented skin lesion was excised under the clinical diagnosis of a pigmented, dysplastic nevus. Histological examination re ...
Fumaric acid esters (FAEs) are effective in patients with moderate to severe psoriasis. Recent studies also report the efficacy of one FAE component, dimethylfumarate, in relapsing forms of multiple sclerosis (MS). We describe the case of a patient with MS who developed severe plaque psoriasis during interferon-β-1a treatment for MS. The psoriasis was unresponsive to usual topical treatments and phototherapy. The patient was started on FAE 720 mg daily, with complete remission of the psoriatic ...
Children with cholestatic liver disease have been thought to develop hepatic osteodystrophy resulting from vitamin D and calcium malabsorption, resulting in secondary hyperparathyroidism and osteomalacia or rickets. However, treatment with vitamin D has not always proven successful in improving the bone disturbance. The aim of our study was to determine the role of vitamin D deficiency in the pathogenesis of hepatic osteodystrophy. We studied five patients, three female and two male, ages 0.9-19 ...
We report the cumulative clinical experience and financial implications of treating severe scalp psoriasis in an outpatient phototherapy center by means of an automated scalp debridement unit. Benefits of this approach included increased patient and staff satisfaction, enhanced response of recalcitrant scalp psoriasis, and detection of scalp dermatoses mimicking psoriasis. ...
BACKGROUND Psoriasis has been considered as a T-helper 1 cell-mediated autoimmune disease driven by collaboration with multiple components of innate and acquired immune cells. Natural killer (NK) cells have been shown to bridge innate and acquired immunity, and thus could potentially contribute to the pathophysiology of psoriasis. OBJECTIVES To investigate the phenotypic changes of circulating NK cells in patients with new-onset psoriasis. METHODS Fifteen patients with plaque psoriasis (eigh ...
Two groups of term newborns with jaundice due to ABO incompatibility were studied to evaluate the action of phenobarbital in diminishing the postphototherapy rebound. Twenty newborns received only prototherapy (group A) and 20 phototherapy plus phenobarbital (group B). Group B received double treatment for 3 days. At that time phototherapy was discontinued mantaining the phenobarbital. The sample to evaluate bilirubinemia in both groups was taken 12-24 hours after discontinuation of phototherapy ...
BACKGROUND Phototherapy is a mainstay in the treatment of psoriasis and other photoresponsive dermatoses and home phototherapy has broadened therapeutic options. PURPOSE To describe the history of home phototherapy, the technological advances in the safety and efficacy of the equipment available, and the associated issues of cost, convenience, adherence, and quality of life. METHODS We conducted a literature review of home phototherapy, broad-band UVB, narrow-band UVB, and PUVA phototherapy ...
Pityriasis rubra pilaris-like eruption associated with the multikinase inhibitor ponatinib To the Editor: Paz et al recently reported a case of a pityriasis rubra pilaris (PRP)-like eruption to the multikinase inhibitor sorafenib. We now report a similar eruption occurring in a patient receiving the third-generation tyrosine kinase inhibitor, ponatinib. These and other recent reports highlight the potential role that medication can play in PRP-like eruptions and may lead to a better understandin ...
Using repeated minimal erythema dose (MED) testing, we investigated the magnitude and duration of tolerance to short-wave UV radiation in the B range (UV-B) in 37 patients with psoriasis who received at least 12 UV-B phototherapy treatments. Without substantial erythema developing, half of the patients received UV-B doses in excess of 13 times their pretreatment MED dose and a fourth received UV-B doses in excess of 28 times their pretreatment MED dose. On average, tolerance faded to about half ...
CONTEXT Identification of factors that enhance the proliferation of human dental mesenchymal stem cells (DMSCs) is vital to facilitate tissue regeneration. The role of low-level laser irradiation (LLLI) on proliferation of human DMSCs has not been well established. OBJECTIVE To assess the effect of LLLI on proliferation of human DMSCs when applied in-vitro. DATA SOURCES Electronic search of literature was conducted (2000-2016) on PubMed, Web of Science, and Scopus databases. Search terms inc ...
BACKGROUND AND OBJECTIVE Swelling and trismus are complications experienced by nearly all subjects after undergoing oral surgery for the removal of impacted teeth. The main purpose of this paper was to compare the effects of photobiomodulation therapy (PBMT) at two different wavelengths applied intra-orally and extra-orally on facial swelling and trismus in the postoperative period following the extraction of impacted mandibular third molars. STUDY DESIGN/MATERIALS AND METHODS Sixty subjects w ...
BACKGROUND The aim of this study was to assess the pharmacokinetics after transdermal administration by a novel skin microdialysis technology in rats. The guinea pig model was established by investigating the pharmacodynamics. MATERIAL AND METHODS Three different agents were given after hair removal, and the samples were extracted by microdialysis and detected by HPLC. Subcutaneous/plasma concentration-time curves of the 3 different agents were analyzed and the pharmacokinetic parameters were ca ...
Skin irradiation with ultraviolet light B (UV-B) and in particular the emission peak at 311 nm represents an effective therapeutic regimen for psoriasis. Excessive tanning, photoaging, and skin cancerization do occur mainly in subjects with skin phototype I to III. The possibility of developing skin cancer is parallel to the skin surface area under treatment and to the overall irradiation dose. We report here on a new focused phototherapy method releasing UV-B with a peak at 311 nm, which consis ...
Objectives: To review the range of thresholds used for treatment of neonatal jaundice at different gestational ages across neonatal units in Great Britain. To investigate the time at which the threshold values plateau, in terms of hours after birth, for various gestational ages. Methods: We contacted 72 neonatal units in Great Britain and enquired about the unit guidelines for management of neonatal jaundice. We requested a copy of the guidelines and jaundice action charts used. Levels for treat ...
Atopic dermatitis is a chronic, relapsing form of eczema characterized by scaling, itchy, inflamed skin that can be triggered by an interplay of genetic, immunologic, and environmental factors. Immune dysregulation appears to play an important role in the cause of atopic dermatitis. Topical corticosteroid agents have been the mainstay of therapy for atopic dermatitis because of their broad immunomodulatory effects. However, topical corticosteroid agents are not ideal agents because when used ove ...
The aim of this study was to analyze the effects of low-level laser therapy (LLLT) on the prevention of cartilage damage after the anterior cruciate ligament transection (ACLT) in knees of rats. Thirty male rats (Wistar) were distributed into three groups (n = 10 each): injured control group (CG); injured laser-treated group at 10 J/cm2 (L10), and injured laser-treated group at 50 J/cm2 (L50). Laser treatment started immediately after the surgery and it was performed for 15 sessions. An 80 ...